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Dr. Shai Efrati is the director of the Sagol center for hyperbaric medicine and research at Assaf-Harofeh Medical Center in Israel. The center, under Dr. Efrati management, has become the largest most occupied hyperbaric center worldwide, currently treating more than 120 patients per day. Dr. Efrati is also the director of Research & Development of Assaf-Harofeh Medical center, affiliated to Tel-Aviv University. Taking the two passions/positions together Dr. Efrati has initiated a research program focusing on the neuroplasticity (regeneration of brain tissue) of Hyperbaric Oxygen Therapy (HBOT). In the first clinical studies it was proved that HBOT can induce neuroplasticity in post stroke and Traumatic Brain Injury even years after the acute Insult. The important clinical results gained from the research program have led to fruitful cooperation including multidiscipline team focusing on regeneration of injured brain due to early stages of dementia, vascular disease and anoxic brain damage as well as other "aging" tissues.